We formulate an S-matrix theory in which finite-size localisation effects of the particle interactions involved in a scattering process are consistently taken into account. In the limit of an infinite spread in the localisation of all interactions, the S-matrix assumes its standard form. To better understand the significance of the emerging quantum phenomena in this formalism, we consider a solvable field-theoretic model with spatial Gaussian spreads at the interaction vertices. This solvable model, enables accurate descriptions of detection regions that are either close to or far from the source. In close analogy with light diffraction in classical optics, we call these two regions near-field and far-field zones, or the Fresnel and Fraunhofer regions. We revisit the question whether mixed mediators produce an oscillating pattern if their detection occurs in the Fresnel region. Besides corroborating certain earlier findings of the S-matrix amplitude in the forward Fresnel and Fraunhofer regimes, we observe several novel features with respect to its angular dependence which have not been accounted before in the literature. In particular, we obtain a 'quantum obliquity factor' that suppresses particle propagation in the backwards direction, thereby providing an explicit quantum field-theoretic description for its origin in diffractive optics. Present and future colliders, as well as both short and long baseline neutrino experiments, would greatly benefit from the many predictions that can be offered from such a holistic S-matrix theory.